Controlled Release of Chlorhexidine from UDMA-TEGDMA Resin

K.J. Anusavice, N.-Z. Zhang and C. Shen

J DENT RES 2006; 85; 950

ABSTRACT
Chlorhexidine salts are available in various formulations for dental applications. This study tested the hypothesis that the release of chlorhexidine from a urethane dimethacrylate and triethylene glycol dimethacrylate resin system can be effectively controlled by the chlorhexidine diacetate content and pH. The filler concentrations were 9.1, 23.1, or 33.3 wt%, and the filled resins were exposed to pH 4 and pH 6 acetate buffers. The results showed that Fickian diffusion was the dominant release mechanism. The rates of release were significantly higher in pH 4 buffer, which was attributed to the increase of chlorhexidine diacetate solubility at lower pH. The higher level of filler loading reduced the degree of polymerization, leading to a greater loss of organic components and higher chlorhexidine release rates.

Link:  http://jdr.sagepub.com/cgi/content/abstract/85/10/950

Tags: composite, dental research, dimethacrylate, esstech, Resin, TEGDMA, Triethyleneglycol, UDMA, urethane, X-850-0000, X-943-7446

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